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NF-kappa B is a ubiquitous family of transcription factors that play an important role in the regulation of genes encoding cytokines and other proteins involved in the host immune response. As the transcriptional activity of NF-kappa B is affected by the binding of regulatory proteins to the transcriptional factors, the role of the inhibitory and enhancing factors in the transcriptional regulation of cytokine gene expression in human monocytes was examined. The recombinant bacteria-expressed inhibitor alpha, an endogenous NF-kappa B inhibitory protein that interferes with the interaction of NF-kappa B subunits with DNA, and the recombinant bacteria-expressed enhancer zeta, a NF-kappa B activating protein that mimics the action of HIV-1 Tat protein, were used to examine the effect of these factors on NF-kappa B-mediated transcription. Treatment of the monocytes with alpha resulted in the inhibition of NF-kappa B-mediated transcription and reduced cytokine gene expression that was dependent on the time of exposure. These results provide evidence of the importance of alpha in the regulation of NF-kappa B transcription and implicate the involvement of endogenous NF-kappa B inhibitory factors in the control of cytokine gene expression in human monocytes.The present invention relates to a novel method for production of low-turbulence aqueous silica gels by hydrolyzing an alkoxysilane in an aqueous solution, and more particularly relates to a new and extremely simple method for controlling the production of silica gels by hydrolysis of alkoxysilanes.
In recent years, there have been a number of attempts to produce gels of silica produced by hydrolysis of alkoxysilanes. For instance, the hydrolysis of tetramethoxys