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* **Photoshop Elements:** `www.adobe.com/products/photoshopelements.html` This is Adobe’s entry-level version of Photoshop. It’s commonly used by professional photographers and anyone who can use layers. * **Photoshop Express:** `www.adobe.com/products/photoshopexpress.html` This is a simplified version of Photoshop used by enthusiasts. Unlike Photoshop, it does not have a database for storing layers. ## The Metaphor of the Camera and the Lens As an analogy, a camera is an image-capturing device. As an analogy, a lens is an image-manipulating device. Because all the features of a camera are tightly coupled with a lens, you can think of a lens as an extension of the camera. You also can think of the camera as a lens. A wide-angle lens is long and narrow, so it lets in more of the scene than a regular lens. A telephoto lens is short and wide, so it lets in less of the scene than a regular lens. This analogy explains why wide-angle lenses are good for landscapes and landscapes, while telephoto lenses are good for objects that come closer to the viewer. ## Focusing Your Lens You focus your lens to make sure that everything in a scene comes into sharp focus, a process that involves changing the curvature of the lens to keep light rays in alignment with the lens. You can focus a lens manually by changing its focal length, or you can use an autofocus setting. When you press the shutter button to take a picture, the lens focuses a scene in front of the lens on the sensor in the camera. The sensor records an image, which is then processed in the camera. So the lens focuses a scene in the world on the sensor. ## Comparing Picture Elements A _picture element_ ( _pixel_ ) is the smallest unit of image that you can see. Therefore, a pixel is an element of light that produces a discernible image when you look at the picture. Pixels are square and defined by a color, as shown in Figure 1-2. You can create images with millions of pixels by reducing the size of pixels until you have fewer than the number of pixels that the sensor can produce. You create a high-resolution image by enlarging pixels until you have more than the number of pixels that the sensor can produce. FIG
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The video tutorial guides you through the most common Photoshop elements editing tools like Levels, Curves, Adjustment Layers, etc. Watching videos is the fastest way to learn anything new. In this video tutorial, I will teach you how to edit and create an interesting design using Photoshop Elements. Here’s what you will learn from this Photoshop tutorial: How to apply, remove, and duplicate an Adjustment Layer How to clone and alter a layer How to increase and reduce the opacity of an image How to use the Adjustment Layers for color manipulation, use color masks and blends How to resizing, crop, and correct the white balance of an image How to add text to images in Photoshop Elements How to remove a layer How to print and print preview There are thousands of ways to resize, color correct and fix and photos. It is up to you to decide which method is best for you and your photos. While the traditional methods of the past work great for some photo editing, Photoshop Elements is a better choice for people that want to learn the basics and get their first steps. Let’s get started. Open Photoshop First open Photoshop Elements. Click on the Organizer in the top left corner, or you can also search for it by using the keyboard shortcut CTRL+E. The Organizer is a great place to find and organize images. You can upload, resize, retouch and even share them. Open an image. Go to File > Open. Click the browse button and navigate to your desired image. Click the Open button and you will be taken to the Open window. Click on the Open button to open it in Photoshop Elements. Open an image. Go to File > Open. Click the browse button and navigate to your desired image. Click the Open button and you will be taken to the Open window. Click on the Open button to open it in Photoshop Elements. Open an image. Go to File > Open. Click the browse button and navigate to your desired image. Click the Open button and you will be taken to the Open window. Click on the Open button to open it in Photoshop Elements. Select an 388ed7b0c7
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otoxins (CTXs) are potent and specific activators of small conductance Ca^2+^-activated K^+^-channels (SK-channels) that regulate many physiologic events including cell proliferation, apoptosis, Ca^2+^ oscillations, cytokinesis, and cellular volume regulation (Watkin et al., [@B141]; Frees and Clapham, [@B48]; Cook et al., [@B35]; Hoppler, [@B63]; Bosch and Villalba, [@B23]; Qu et al., [@B106]). Selective activation of SK channels by CTXs causes a resting membrane potential hyperpolarization, inhibits cell proliferation and cell survival, and promotes cell cycle arrest and apoptosis by a unique mechanism. The SK channel-mediated processes are orchestrated by cytosolic and plasma membrane Ca^2+^ and membrane phospholipids (PIP~2~) signaling pathways and protein kinase C (PKC) activation (Chidlow et al., [@B31]; Frees and Clapham, [@B48]; Cook et al., [@B35]; Olmos et al., [@B97]; Chidlow and Kuno, [@B30]; Wulle et al., [@B143]; Gradinaru et al., [@B56]). The SK channels are ligand-gated Ca^2+^-permeable channels composed of 12 subunits (alpha, beta, gamma, delta, and epsilon) known as SK1–SK4 channels (Fitches et al., [@B46]). The SK channels are activated by both cytosolic and plasma membrane Ca^2+^ (Hashimoto et al., [@B60]). The lumenal amino acids (a.a.) predicted to form one Ca^2+^ binding site in SK1–SK4 channels show wide variations, including SK1–SK4 alpha-helices, periplasmic loop regions, the extracellular loop regions, the loop connecting transmembrane domain II and III, and the cytoplasmic tail (Chidlow et al., [@B31]). Three sequence motifs, the SxFSKxT motif, the SxDFTV motif, and the polyamine binding site (PBS) characterized as SK1–SK4 channel-specific sequence
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